913669

Biotinamidoethyldisulfanyl(2-aminoethane) trifluoroacetic acid

• Synonym(s): N-(2-((2-Aminoethyl)disulfaneyl)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide 2,2,2-trifluoroacetate, Biotin-SS-NH₂ TFA, Biotin-cystamine TFA, Cleavable biotin linker
• Empirical Formula (Hill Notation): C₁₆H₂₇F₃N₄O₄S₃
• CAS Number: 880491-09-8
• Molecular Weight: 492.60
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• form: powder
• Quality Level: 100
• storage temp.: −20°C
• SMILES string: OC(C(F)(F)F)=O.NCCSSCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O

Description

Application

Biotinamidoethyldisulfanyl(2-aminoethane) trifluoroacetic acid (Biotin-SS-NH₂ TFA) is a cleavable, biotinylated crosslinkers. The linker can also be used for synthesis of chemical biology tools for labeling target proteins in biological experiments and assays. It possesses dual functionality: enrichment via the biotin and an embedded disulfide bridge for cleavage under reducing conditions.

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Other Notes

Fluorometric assay for tissue transglutaminase-mediated transamidation activity

Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

A simple photo-affinity labeling protocol

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable