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852228

Sigma-Aldrich

2′-Deoxyguanosine 5′-monophosphate disodium salt hydrate

≥98%

Synonym(s):

2′-Deoxy-5′-guanylic acid disodium salt, 5′-dGMP disodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H12N5Na2O7P · xH2O
CAS Number:
33430-61-4
Molecular Weight:
391.18 (anhydrous basis)
MDL number:
MFCD00150758
UNSPSC Code:
41106305
PubChem Substance ID:
24888319
NACRES:
NA.22

Quality Level

100

Assay

≥98%

form

solid

impurities

≤4% ethanol

mp

>245 °C (dec.) (lit.)

SMILES string

[Na+].[Na+].[H]O[H].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])([O-])=O)O3)C(=O)N1

InChI

1S/C10H14N5O7P.2Na.H2O/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20;;;/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17);;;1H2/q;2*+1;/p-2/t4-,5+,6+;;;/m0.../s1

InChI key

HQSJCEYJAGVPJG-BIHLCPNHSA-L

Application

Reactant involved in:
  • Analysis of self-assembling in solution and nucleation / growth of G-qudruplexes
  • Nucleophilic trapping
  • Reductive alkylation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT8839
MKCM8926
MKCD5079
MKBX5619V
MKBW7986V

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Mariko Higuchi et al.
Journal of structural biology, 173(1), 20-28 (2010-10-05)
MutT distinguishes substrate 8-oxo-dGTP from dGTP and also 8-oxo-dGMP from dGMP despite small differences of chemical structures between them. In this paper we show by the method of molecular dynamics simulation that the transition between conformational substates of MutT is
Yancheng Liu et al.
Journal of photochemistry and photobiology. B, Biology, 118, 58-65 (2012-12-12)
Photochemical properties and phototoxicity of Pazufloxacin (PAX) were systematically investigated in aqueous solutions using UV-Vis, fluorescence, laser flash photolysis, pulse radiolysis and SDS-PAGE gel electrophoresis techniques. PAX triplet-state ((3)PAX(*)) absorption spectra (λ(max)=570 nm) was determined. (3)PAX(*) was quenched by PAX
Alireza Ariafard et al.
Inorganic chemistry, 52(2), 707-717 (2012-12-29)
The mechanism for the oxidation of 3'-dGMP by [PtCl(4)(dach)] (dach = diaminocyclohexane) in the presence of [PtCl(2)(dach)] has been investigated using density functional theory. We find that the initial complexation, i.e., the formation of [PtCl(3)(dach)(3'-dGMP)], is greatly assisted by the
Francois-Alexandre Miannay et al.
The journal of physical chemistry. A, 114(9), 3256-3263 (2010-01-21)
The room-temperature fluorescence of 2'-deoxyguanosine 5'-monophosphate (dGMP) in aqueous solution is studied by steady-state and time-resolved fluorescence spectroscopy. The steady-state fluorescence spectrum of dGMP shows one band centered at 334 nm but has an extraordinary long red tail, extending beyond
Mahmoud Kandeel et al.
Nucleic acids symposium series (2004), (53)(53), 39-40 (2009-09-15)
In Plasmodium falciparum, deoxyguanylate was found to be a substrate for several DNA metabolizing enzymes. Guanylate kinase utilizes dGMP with very low specificity, which is estimated to be the lowest among well-known prokaryotic and eukaryotic enzymes. Furthermore, thymidylate kinase, which
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