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808628

Sigma-Aldrich

Gold nanoparticles

5 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O

Synonym(s):

Biotin Gold

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About This Item

EC Number:
231-791-2
UNSPSC Code:
12141717
NACRES:
NA.23

material

PEG 5000

Quality Level

100

form

dispersion in H2O
nanoparticles

packaging

pkg of 0.5 mL

OD

50

surface area

6.18 m2/g

diameter

5 nm

pH

5-7

density

1.00 g/cm3

λmax

513-517 nm

functional group

biotin

storage temp.

2-8°C

InChI

1S/Au

InChI key

PCHJSUWPFVWCPO-UHFFFAOYSA-N

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General description

Gold nanoparticles PEG 5000 biotin terminated.

Application

Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent, and ranges from 515-520 nm for a 5 nm particle to 572 nm for a 100 nm particle.
Gold nanoparticles 5 nm diameter, biotin terminated, PEG 5000 coated, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR7757
MKCR9875
MKCQ3560
MKCN6286
MKCL2899

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Gold nanoparticles

Motao Zhu et al.
ACS nano, 14(3), 3703-3717 (2020-02-15)
Engineered nanoparticles could trigger inflammatory responses and potentiate a desired innate immune response for efficient immunotherapy. Here we report size-dependent activation of innate immune signaling pathways by gold (Au) nanoparticles. The ultrasmall-size (<10 nm) Au nanoparticles preferentially activate the NLRP3
Localized surface plasmon resonance (LSPR) of polyelectrolyte-functionalized gold-nanoparticles for bio-sensing
Li X, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 332(2-3), 172-179 (2009)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo DN, et al.
Biomaterials, 33(3), 856-866 (2012)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 33(6), 666-680 (2020)
Colorimetric biosensing of pathogenss using gold nanoparticles
Verma MS, et al.
Biotechnology Advances, 33(6), 666-680 (2015)
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