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678937

Sigma-Aldrich

Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine

97%

Synonym(s):

TBTA

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About This Item

Empirical Formula (Hill Notation):
C30H30N10
CAS Number:
510758-28-8
Molecular Weight:
530.63
MDL number:
MFCD09265124
UNSPSC Code:
12161600
PubChem Substance ID:
24884865
NACRES:
NA.22

Quality Level

200

Assay

97%

form

solid

reaction suitability

reagent type: ligand
reaction type: click chemistry

mp

132-143 °C

storage temp.

−20°C

SMILES string

C(N(Cc1cn(Cc2ccccc2)nn1)Cc3cn(Cc4ccccc4)nn3)c5cn(Cc6ccccc6)nn5

InChI

1S/C30H30N10/c1-4-10-25(11-5-1)16-38-22-28(31-34-38)19-37(20-29-23-39(35-32-29)17-26-12-6-2-7-13-26)21-30-24-40(36-33-30)18-27-14-8-3-9-15-27/h1-15,22-24H,16-21H2

InChI key

WKGZJBVXZWCZQC-UHFFFAOYSA-N

Related Categories

Application

A polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.

related product

Product No.
Description
Pricing

906301

BTTES

906328

BTTAA, ≥95%

Hazard Statements

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF0600V
WXBD8776V
MKCQ4523
MKCK8109
MKCH1117

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Frank Iversen et al.
Theranostics, 3(3), 201-209 (2013-03-09)
Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of polyethylene glycol (PEG) with variable chain
Brent R Martin et al.
Nature methods, 9(1), 84-89 (2011-11-08)
The reversible thioester linkage of palmitic acid on cysteines, known as protein S-palmitoylation, facilitates the membrane association and proper subcellular localization of proteins. Here we report the metabolic incorporation of the palmitic acid analog 17-octadecynoic acid (17-ODYA) in combination with
Timothy R Chan et al.
Organic letters, 6(17), 2853-2855 (2004-08-28)
Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.
Qian Wang et al.
Journal of the American Chemical Society, 125(11), 3192-3193 (2003-03-13)
The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently in aqueous solution in the presence of a tris(triazolyl)amine ligand. The process has been employed to make rapid and reliable covalent connections to micromolar concentrations of protein decorated with either
Xiangyu Zhang et al.
Therapeutic advances in medical oncology, 12, 1758835920947976-1758835920947976 (2020-10-01)
Aspirin has recently emerged as an anticancer drug, but its therapeutic effect on lung cancer has been rarely reported, and the mechanism of action is still unclear. Long-term use of celecoxib in large doses causes serious side effects, and it
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