378674

Carbendazim

97%

• Synonym(s): BCM, Methyl 2-benzimidazolecarbamate, Methyl benzimidazol-2-ylcarbamate
• Empirical Formula (Hill Notation): C₉H₉N₃O₂
• CAS Number: 10605-21-7
• Molecular Weight: 191.19
• Beilstein: 649044
• EC Number: 234-232-0
• MDL number: MFCD00055390
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863567
• NACRES: NA.22

Properties

• Assay: 97%
• form: powder
• mp: >300 °C (lit.)
• solubility: pyridine: soluble 1%, clear, very faintly brownish-yellow
• functional group: amine
• SMILES string: COC(=O)Nc1nc2ccccc2[nH]1
• InChI: 1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)
• InChI key: TWFZGCMQGLPBSX-UHFFFAOYSA-N

Description

General description

Carbendazim is a systemic broad-spectrum fungicide, used worldwide against various fungal diseases of agricultural products. It is reported to pose deleterious effects on the human placental trophoblast cells. Dissipation pattern and risk assessment of carbendazim and mancozeb in mango fruits has been reported. The influence of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules and sperm of adult rat has been determined. Fast and sensitive method of determination of carbendazim (methyl benzimidazole-2-ylcarbamate, MBC) in water and soil samples has been developed by using dispersive liquid-liquid microextraction (DLLME) coupled with HPLC with fluorescence detection. Reaction kinetics of the transformation of the fungicide carbendazim induced by hydroxyl radical generated by the UV photolysis of H₂O₂ has been studied.

Application

Carbendazim (Methyl 2-benzimidazolecarbamate, Methyl benzimidazol-2-ylcarbamate) has been used in the following studies:

• As positive control in direct contact assay (mycelial radial growth inhibition assay).
• As pesticide and its effect on the transcription responses of Enchytraeus albidus have been studied.
• As broad-spectrum antifungal compound, to study the antibacterial action of anti-tuberculosis drugs against Mycobacterium tuberculosis in the Dubos broth culture medium.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H317,H340,H360FD,H410
• Precautionary Statements: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 1B - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves