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272264

Sigma-Aldrich

1-(3-Aminopropyl)imidazole

≥97%

Synonym(s):

1-(3-Aminopropanyl)imidazole, 3-(1-Imidazolyl)propylamine, 3-(1H-Imidazol-1-yl)propylamine, 3-(Imidazol-1-yl)propylamine, N-(3-Aminopropyl)imidazole, N-[3-(1H-Imidazol-1-yl)propyl]amine

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About This Item

Empirical Formula (Hill Notation):
C6H11N3
CAS Number:
5036-48-6
Molecular Weight:
125.17
EC Number:
225-730-9
MDL number:
MFCD00009819
UNSPSC Code:
12352005
PubChem Substance ID:
24856463
NACRES:
NA.22

Quality Level

100

Assay

≥97%

form

liquid

refractive index

n20/D 1.519 (lit.)

density

1.049 g/mL at 25 °C (lit.)

functional group

amine

SMILES string

NCCCn1ccnc1

InChI

1S/C6H11N3/c7-2-1-4-9-5-3-8-6-9/h3,5-6H,1-2,4,7H2

InChI key

KDHWOCLBMVSZPG-UHFFFAOYSA-N

Application

1-(3-Aminopropyl)imidazole was used in the synthesis of pH-sensitive polyaspartamide derivatives. It was also used in the preparation of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution by graft reaction.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H314,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

309.2 °F

Flash Point(C)

154 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF4196V
WXBF2123V
WXBF1304V
WXBD9042V
MKCR1932

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Sigma-Aldrich

CDS007822

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Kwangwon Seo et al.
Journal of nanoscience and nanotechnology, 10(10), 6986-6991 (2010-12-09)
The effect of hydrophobic octadecyl groups on pH-dependent aggregation behavior of polyaspartammide derivatives was studied. A series of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution were synthesized through a successive graft reaction of octaceylamine, O-(2-aminoethyl)-O'-methylpolyethylene glycol, and
Abootaleb Sedighi et al.
Talanta, 186, 568-575 (2018-05-23)
Several solution-based methods have recently been adapted for use in paper substrates for enzymatic amplification to increase the number of copies of DNA sequences. There is limited information available about the impact of a paper matrix on DNA amplification by
Taehoon Sim et al.
Pharmaceutics, 12(9) (2020-09-06)
Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a
Kwangwon Seo et al.
Macromolecular bioscience, 6(9), 758-766 (2006-09-13)
New pH-sensitive polyaspartamide derivatives were synthesized by grafting 1-(3-aminopropyl)imidazole and/or O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) 5000 on polysuccinimide for application in intracellular drug delivery systems. The DS of 1-(3-aminopropyl)imidazole was adjusted by the feed molar ratio, and the structure of the prepared polymer
Di Lu et al.
AAPS PharmSciTech (2018-06-20)
The complex design of multifunctional nanomedicine is beneficial to overcome the multiple biological barriers of drug delivery, but it also presents additional hurdles to clinical translation (e.g., scaling-up and quality control). To address this dilemma, we employed a simple imidazole-bearing
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