235229
Methyl dichlorophosphite
technical grade
Synonym(s):
Methyl phosphorodichloridite
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About This Item
Linear Formula:
CH3OPCl2
CAS Number:
Molecular Weight:
132.91
Beilstein:
1697452
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
grade
technical grade
Quality Level
form
liquid
refractive index
n20/D 1.474 (lit.)
bp
93-95 °C (lit.)
mp
−91 °C (lit.)
density
1.376 g/mL at 20 °C (lit.)
SMILES string
COP(Cl)Cl
InChI
1S/CH3Cl2OP/c1-4-5(2)3/h1H3
InChI key
HCSDJECSMANTCX-UHFFFAOYSA-N
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Application
Methyl dichlorophosphite has been employed in the preparation of:
- phosphonamidate- and phosphonate-linked phosphonopeptides
- 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol
- deoxyoligonucleotides on a polymer support
- cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane
- phosphorodichloridothioates
- oxazaphosphorinanes
accessory
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3
Target Organs
Respiratory system
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
77.0 °F - closed cup
Flash Point(C)
25 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Nanyan Fu et al.
Journal of peptide science : an official publication of the European Peptide Society, 12(4), 303-309 (2005-10-26)
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl
Synthesis and enantioselective aldol reaction of a chiral 2-oxo-2-propionyl-1, 3, 2-oxazaphosphorinane.
Gordon NJ and Evans Jr SA.
The Journal of Organic Chemistry, 58(20), 5295-5297 (1993)
Synthesis of deoxyoligonucleotides on a polymer support.
Matteucci MD and Caruthers MH.
Journal of the American Chemical Society, 103(11), 3181-3191 (1981)
T Tanaka et al.
Nucleic acids research, 10(10), 3249-3260 (1982-05-25)
A simple procedure is described for synthesis of oligonucleotides by phosphate chemistry. Chains can be constructed rapidly with minimal equipment (a syringe and reagent bottles). The method is illustrated by synthesis of d-TGCAGGTT. Pertinent supporting data on the effect of
Synthetic Communications, 22, 289-289 (1992)
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