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226017

Sigma-Aldrich

1,2-Naphthoquinone-4-sulfonic acid sodium salt

97%

Synonym(s):

3,4-Dihydro-3,4-dioxo-1-naphthalenesulfonic acid sodium salt, Folin’s reagent, Sodium 1,2-naphthoquinone-4-sulfonate

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About This Item

Empirical Formula (Hill Notation):
C10H5NaO5S
CAS Number:
521-24-4
Molecular Weight:
260.20
Beilstein:
4169788
EC Number:
208-308-9
MDL number:
MFCD00001700
UNSPSC Code:
12352100
PubChem Substance ID:
24853538
NACRES:
NA.22

Assay

97%

form

powder

mp

289 °C (dec.) (lit.)

solubility

alcohol: slightly soluble 95%
acetone: moderately soluble(lit.)
benzene: insoluble(lit.)
carbon disulfide: insoluble(lit.)
chloroform: insoluble(lit.)
diethyl ether: insoluble(lit.)
petroleum ether: insoluble(lit.)
water: soluble(lit.)

functional group

ketone
sulfonic acid

SMILES string

[Na+].[O-]S(=O)(=O)C1=CC(=O)C(=O)c2ccccc12

InChI

1S/C10H6O5S.Na/c11-8-5-9(16(13,14)15)6-3-1-2-4-7(6)10(8)12;/h1-5H,(H,13,14,15);/q;+1/p-1

InChI key

UBLXEEBHYISRFM-UHFFFAOYSA-M

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Application

1,2-Naphthoquinone-4-sulfonic acid sodium salt (Folin′s reagent) was used in the colorimetric assay for determination of procaine hydrochloride in pharmaceutical preparations.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL9819
BCCM0764
BCCM0763
BCCK6980
BCCK9720

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R B Salama et al.
Journal of pharmaceutical sciences, 69(3), 346-348 (1980-03-01)
A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react
Linjin Ma et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(3), 599-602 (2011-05-03)
Boron determination by a charge transfer spectrophotometric method is described. Accompanied the reaction, a charge transfer complex can be formed by lysine with sodium 1, 2-naphthoquinone-4-sulfonate and boron in alkaline solution (pH 12.00). Subsequently, a new reaction mechanism has been
Natividad García-Villar et al.
Electrophoresis, 27(2), 474-483 (2005-12-07)
A sensitive CE method for determining biogenic amines in wines based on in-capillary derivatization with 1,2-naphthoquinone-4-sulfonate is presented. In this method, reagent and buffer solutions are introduced hydrodynamically into the capillary whereas the sample is injected electrokinetically, thus, allowing a
Ibrahim A Darwish et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(4), 897-902 (2009-01-13)
Spectrophotometric study was carried out, for the first time, to investigate the reaction between the antidepressant fluvoxamine (FXM) and 1,2-naphthoquinone-4-sulphonate (NQS) reagent. In alkaline medium (pH 9), an orange-colored product exhibiting maximum absorption peak (lambda(max)) at 470nm was produced. The
Huai You Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(12), 2933-2939 (2004-09-08)
Spectrophotometric determination of dapsone is described. The dapsone reacts with sodium 1,2-naphthoquinone-4-sulfonic in pH 6.98 buffer solution to form a salmon pink compound, and its maximum absorption wavelength is at 525 nm, epsilon525=3.68 x 10(4) l mol(-1) cm(-1). The absorbance
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