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166375

Sigma-Aldrich

Formic hydrazide

Synonym(s):

Formic acid hydrazide, Formylhydrazine

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About This Item

Linear Formula:
HCONHNH2
CAS Number:
Molecular Weight:
60.06
Beilstein:
635759
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

mp

52-57 °C (lit.)

solubility

water: soluble 2.5%, clear, colorless

functional group

amine
hydrazine

SMILES string

[H]C(=O)NN

InChI

1S/CH4N2O/c2-3-1-4/h1H,2H2,(H,3,4)

InChI key

XZBIXDPGRMLSTC-UHFFFAOYSA-N

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Application

Formic hydrazide was used in the synthesis of 1,2,4-triazole derivatives. It was also used in the synthesis of new anticancer agent, 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7(6H)-dione.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

233.6 °F - closed cup

Flash Point(C)

112 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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B Toth et al.
Carcinogenesis, 1(1), 61-65 (1980-01-01)
N-ethyl-N-formylhydrazine (EFH) was administered as a 0.02% solution in drinking water continuously for life to randomly bred Swiss mice, from 6 weeks of age. The treatment induced tumors of the lungs, blood vessels, liver, gall bladder and preputial glands. The
Traceless liquid-phase synthesis of 3-alkylamino-4, 5-disubstituted-1, 2, 4-triazoles on polyethylene glycol (PEG).
Zong Y-X, et al.
Tetrahedron Letters, 46(31), 5139-5141 (2005)
Synthesis of NB-506, a new anticancer agent.
Ohkubo M, et al.
Tetrahedron, 53(2), 585-592 (1997)
Coro Echeverría et al.
Polymers, 11(6) (2019-06-05)
Nano-sized one-dimensional metallo-organic polymers, characterized by the phenomenon of spin transition, are excellent candidates for advanced technological applications such as optical sensors, storage, and information processing devices. However, the main drawback of this type of polymers is their fragile mechanical

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