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117323

Sigma-Aldrich

4,4′-Methylene-bis(2-chloroaniline)

85%

Synonym(s):

2,2′-Dichloro-4,4′-methylenedianiline, 4,4′-Diamino-3,3′-dichlorodiphenylmethane

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About This Item

Linear Formula:
CH2[C6H3(Cl)NH2]2
CAS Number:
101-14-4
Molecular Weight:
267.15
Beilstein:
1882318
EC Number:
202-918-9
MDL number:
MFCD00047829
UNSPSC Code:
12162002
PubChem Substance ID:
24847326
NACRES:
NA.23

Quality Level

100

Assay

85%

form

solid

bp

202-214 °C/0.3 mmHg (lit.)

mp

102-107 °C (lit.)

SMILES string

Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl

InChI

1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2

InChI key

IBOFVQJTBBUKMU-UHFFFAOYSA-N

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Related Categories

Signal Word

Danger

Hazard Statements

H302,H341,H350,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

EU REACH Annex XIV (Authorisation List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW1243
MKCN2975
MKCJ8669
MKCF1405
MKBZ8295V

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L Luukkanen et al.
Pharmacology & toxicology, 80(3), 152-158 (1997-03-01)
Rats were treated with acetone, pyrazole, phenobarbital, 4,4'-methylenebis-(2-chloroaniline) (MOCA), 3-methylcholanthrene, creosote oil, or a mixture of polychlorinated biphenyls (Aroclor 1254) to study the inducibility and enzyme kinetics of UDP-glucuronosyltransferases towards 1-hydroxypyrene, which is a human metabolite and a urinary biomarker
M Schuler et al.
Mutation research, 392(1-2), 81-95 (1997-08-01)
The in vitro micronucleus assay in conjunction with CREST-staining and fluorescence in situ hybridization (FISH) with centromere-specific DNA probes is being increasingly utilized for the detection of clastogenic and aneuploidy-inducing agents. Although potentially powerful techniques, both methods have unique characteristics
Wei-Chung Shih et al.
Rapid communications in mass spectrometry : RCM, 21(24), 4073-4078 (2007-11-17)
Analysis of 4,4'-methylenebis(2-cholroaniline) (MOCA) or its metabolites in urine has been considered as the appropriate method to assess MOCA exposures through inhalation and skin absorption. MOCA and its metabolite, N-acetyl 4,4'-methylenebis(2-chloroaniline) (acetyl-MOCA), are analyzed using methods either limited by sensitivity
4,4'-Methylenebis(2-chloroaniline).
Report on carcinogens : carcinogen profiles, 10, 149-151 (2004-08-26)
Hong-I Chen et al.
Journal of occupational health, 49(5), 389-398 (2007-10-24)
Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between
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