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vapor density
4.65 (vs air)
Quality Level
vapor pressure
1 mmHg ( 114 °C)
Assay
99%
form
solid
autoignition temp.
1004 °F
bp
304 °C (lit.)
mp
113-115 °C (lit.)
functional group
amide
SMILES string
CC(=O)Nc1ccccc1
InChI
1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
InChI key
FZERHIULMFGESH-UHFFFAOYSA-N
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General description
Acetanilide undergoes palladium-catalyzed cross-coupling reaction to form ortho-acylacetanilide.
Application
Acetanilide is used as a EOF (electroosmotic flow) marker in the studies of affinity capillary electrophoresis for drug–protein binding.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
321.8 °F - closed cup
Flash Point(C)
161 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Journal of pharmaceutical and biomedical analysis, 52(2), 232-241 (2010-01-19)
In order to achieve excellent precision in the estimation of binding constants by affinity capillary electrophoresis (ACE), electroosmotic flow (EOF) stability is the key parameter, especially when using proteins in binding assays. Appropriate rinsing protocols are mandatory. In our study
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Chemical communications (Cambridge, England), 49(7), 689-691 (2012-12-12)
A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl precursors (upon sp(3)-C-H bond oxidation by a Pd/TBHP system) in the oxidative coupling between two C-H bonds. This
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