569232-U
Discovery® C18 (5 µm) HPLC Columns
L × I.D. 12.5 cm × 4.6 mm, HPLC Column
Synonym(s):
Discovery RP18 HPLC Column
About This Item
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product name
Discovery® C18 HPLC Column, 5 μm particle size, L × I.D. 12.5 cm × 4.6 mm
material
stainless steel column
Agency
suitable for USP L1
product line
Discovery®
feature
endcapped
manufacturer/tradename
Discovery®
packaging
1 ea of
extent of labeling
12% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
12.5 cm × 4.6 mm
surface area
300 m2/g
surface coverage
3 μmol/m2
impurities
<10 ppm metals
matrix
silica gel, high purity, spherical particle platform
fully porous particle
matrix active group
C18 (octadecyl) phase
particle size
5 μm
pore size
180 Å
operating pH range
2-8
application(s)
food and beverages
separation technique
reversed phase
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General description
Application
- Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson′s Disease Candidate, Using LC-MS/MS and LC-HRMS.: This study underscores the utility of theDiscovery® C18 HPLC Column in pharmacokinetic profiling and metabolite identification of a novel therapeutic agent, demonstrating its critical role in the development of Parkinson′s disease treatments (Choi et al., 2024).
- Determination of 2,4-dimethylhydroxybenzene by chromatographic methods in forensic toxicological research of biological material.: Highlights the application of the Discovery® C18 HPLC Column in forensic toxicology, enhancing the detection and quantification of toxic substances within biological samples, vital for legal and medical investigations (Chernova et al., 2024).
- High-throughput microfluidic chip with silica gel-C18 channels for cyclotide separation.: Illustrates the integration of the Discovery® C18 HPLC Column in a microfluidic setting for efficient and high-throughput separation of cyclotides, offering advancements in peptide and protein analysis (Ebrahimi et al., 2023).
- Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention.: This research utilizes the Discovery® C18 HPLC Column for the advanced study of microbial metabolism under nanoparticle intervention, pushing the boundaries of biotechnological and pharmaceutical research (Al-Theyab et al., 2023).
- A practical strategy enabling more reliable identification of ginsenosides from Panax quinquefolius flower by dimension-enhanced liquid chromatography/mass spectrometry and quantitative structure-retention relationship-based retention behavior prediction.: Demonstrates the versatility of the Discovery® C18 HPLC Column in complex botanical analyses, particularly in enhancing the reliability of ginsenoside identification, crucial for the development of herbal medicinal products (Sun et al., 2023).
Features and Benefits
- Excellent reproducibility
- Exceptional peak shape for basic and acidic analytes
- Stable, low-bleed LC-MS separations
- Separation of peptides and small proteins
- Lower hydrophobicity than many comparable C18 columns, providing faster analysis
Legal Information
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