TRUECD
TrueGel3D Crosslinker
CD cell-degradable crosslinker
Synonym(s):
Crosslinker
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About This Item
UNSPSC Code:
12352207
NACRES:
NA.52
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shipped in
dry ice
storage temp.
−20°C
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General description
CD cell-degradable crosslinker is comprised of conjugated peptide along with polyethylene glycol and thiol (SH) groups. The thiol groups form stable thioether bond with thiol-reactive groups of the polymers (Mal-PVA, Mal-Dextran, SG-PVA and SG-Dextran) and results in a stable hydrogel.
The conjugated peptide has matrix metalloprotease (MMP)-cleavage sites (Pro-Leu-Gly-Leu-Trp-Ala), which allows matrix metalloproteases (MMP1, MMP3, MMP7 and MMP9) to locally degrade the polymer network. It allows cells to spread and migrate within the gel if they express the indicated MMPs.
The conjugated peptide has matrix metalloprotease (MMP)-cleavage sites (Pro-Leu-Gly-Leu-Trp-Ala), which allows matrix metalloproteases (MMP1, MMP3, MMP7 and MMP9) to locally degrade the polymer network. It allows cells to spread and migrate within the gel if they express the indicated MMPs.
Application
TRUECD is used to crosslink PVA and dextran polymers to generate cell-degradable hydrogel
Features and Benefits
MMP degradable
Components
TRUECD contains CD cell-degradable crosslinker lyophilized and water.
Caution
Avoid prolong exposure of CD cell-degradable crosslinker to air
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
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