SML3350

Acriflavine purified

≥95% (HPLC)

• Synonym(s): Mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinehydrochloride) and proflavine (3,6-diaminoacridine) hydrochloride
• Linear Formula: [C₁₃H₁₁N₃.HCl]x·[C₁₄H₁₃N₃.HCl]y ·[C₁₄H₁₄N₃·Cl]z
• UNSPSC Code: 12352200
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: red to brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC1=CC2=C(C=C1)C=C3C=CC(N)=CC3=N2.NC4=CC5=C(C=C4)C=C6C=CC(NC)=CC6=N5.NC7=CC8=C(C=C7)C=C9C=CC(N)=CC9=[N+]8C.[Cl-].Cl.Cl

Description

Biochem/physiol Actions

Acriflavine is an antimicrobial drug used to treat against sleeping sickness, urinary tract infections, and gonorrhea. Acriflavine is a potent inhibitor of SARS-CoV-2 papain-5 like protease (PLpro), which potently inhibits viral replication in vivo in mice and ex vivo in human airway epithelia. It is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine). Apparently commercial acriflavine mixtures contain the combination of differently methylated proflavines to optimally block the PLpro active site. Also, it potently inhibits replication of other betacoronaviruses.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable