SML2203

SGC-GAK-1N

≥98% (HPLC)

• Synonym(s): CA71, CA93 Negative Control, N-Methyl-6-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine, SGC-GAK-1 Negative Control
• Empirical Formula (Hill Notation): C₂₀H₁₉F₃N₂O₃
• CAS Number: 2226517-74-2
• Molecular Weight: 392.37
• UNSPSC Code: 41106609
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: dark green to black
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(C1=CC(OC)=C(OC)C(OC)=C1)C2=C3C(C=CC(C(F)(F)F)=C3)=NC=C2

Description

Biochem/physiol Actions

SGC-GAK-1N (CA71) is a structure analog of and the recommended negative control for the ATP-competitive cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 (CA93) (GAK K_D = 1.9 nM/SGC-GAK-1 vs. 7.1 μM/SGC-GAK-1N by ligand competitive binding assay; GAK IC50 = 110 nM/SGC-GAK-1 vs. >50 μM/SGC-GAK-1N by cellular target engagement assay; Dengue viral entry and packaging IC50 = 920 nM/SGC-GAK-1 vs. >10 μM/SGC-GAK-1N). For characterization details of the active probe, SGC-GAK-1, please visit the SGC-GAK-1 probe summary on the Structural Genomics Consortium (SGC) website.

SGC-GAK-1, the active probe, is available from Sigma. To learn more about and purchase SGC-GAK-1, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc

Features and Benefits

SGC-GAK-1N is a negative control for SGC-GAK-1, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable