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Key Documents

SAB4504665

Sigma-Aldrich

Anti-phospho-BL-CAM (pTyr807) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 95 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

P20273

UniProt accession no.

P20273

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr807)

Gene Information

human ... CD22(933)

General description

CD22 (cluster of differentiation 22) is a 140 kDa single-spanning membrane glycoprotein present on the surface of B cells. This gene belongs to the sialic acid-binding Ig-type lectin (Siglec) family. CD22 is mapped to human chromosome 19q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human BL-CAM around the phosphorylation site of Tyr807.

Immunogen Range: 776-825

Biochem/physiol Actions

CD22 (cluster of differentiation 22) helps to maintain B-cell homeostasis. This molecule act as an inhibitory coreceptor of the BCR (B cell receptor). CD22 is considered as a response regulator to control several aspects of B cell functions. Deficiency in CD22 or its pathways may contribute to autoimmunity.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
Fujimoto M, et al.
Journal of Immunology, 176(2), 873-879 (2006)
High Resolution Crystal Structures of Siglec-7 INSIGHTS INTO LIGAND SPECIFICITY IN THE SIGLEC FAMILY.
Alphey MS, et al.
The Journal of Biological Chemistry, 278(5), 3372-3377 (2003)
Molecular basis of human CD22 function and therapeutic targeting.
Ere?o-Orbea J, et al.
Nature Communications, 8(1), 764-764 (2017)
Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model.
Bednar KJ, et al.
Journal of Immunology, 199(9), 3116-3128 (2017)

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