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SAB2500781

Sigma-Aldrich

Anti-PGC1A antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-LEM6, Anti-PPARGC1A, Anti-Peroxisome proliferator-activated receptor γ

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, canine, rat

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

General description

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) encodes the 798 amino acid protein, PGC-1α. It is a multifunctional transcriptional protein, which belongs to the family of transcription co-activators involved in the regulation of cellular energy metabolism. PGC-1α is abundantly expressed in several human tissues that are active in oxidative metabolism, including heart, skeletal muscle, and the fasted liver. The gene encoding this protein is localized on human chromosome 4p15.1-2.

Immunogen

Peptide with sequence C-DGLFDDSEDESDK from the internal region of the protein sequence according to NP_037393.1.

Application

Anti-PGC1A antibody produced in goat has been used in Western blotting.

Biochem/physiol Actions

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) modulates the expression of mitochondrial oxidative phosphorylation (OXPHOS) genes and endogenous antioxidants. Variation in the gene expression leads to Huntington′s disease (HD) and Type 2 diabetes. PGC-1α functions as a ‘molecular switch′ in genetic pathways involved in maintaining glucose homeostasis in liver and muscle, β cell insulin secretion and mitochondrial biogenesis. Addition to this, PGC-1α has a crucial role to play in adaptive thermogenesis, skeletal muscle fiber type switching and heart development. PGC-1α reduces or improves muscle dystrophy by stimulating various molecular pathways; therefore, increase in the concentration and activity of PGC-1 is considered to be a potential method for Duchene muscular dystrophy (DMD) treatment.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Customers Also Viewed

A PGC-1? isoform induced by resistance training regulates skeletal muscle hypertrophy.
Ruas JL
Cell, 151(6), 1319-1331 (2012)
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Handschin C
Genes & Development, 21(7), 770-783 (2007)
Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)
Benjamin L. Farah
Nature, 7 (2017)
PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes.
Soyal S
Diabetologia, 49(7), 1477-1488 (2006)
PGC-1alpha: a key regulator of energy metabolism.
Liang H and Ward WF
Advances in Physiology Education, 30(4), 145-151 (2006)

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