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(R)-(+)-Propranolol hydrochloride

Name: (<I>R</I>)-(+)-Propranolol hydrochloride
Brand: SIGMA

≥98% (TLC), Beta-adrenergic antagonist

Synonym(s):

Propranolol HCl, (R)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride

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About This Item

Linear Formula:

C₁₀H₇OCH₂CH(OH)CH₂NHCH(CH₃)₂·HCl

CAS Number:

13071-11-9

Molecular Weight:

295.80

NACRES:

NA.77

PubChem Substance ID:

24898124

UNSPSC Code:

12352200

EC Number:

235-961-7

MDL number:

MFCD00064546

Beilstein/REAXYS Number:

5780490

Assay:

≥98% (TLC)

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Properties

Product Name

(R)-(+)-Propranolol hydrochloride, ≥98% (TLC)

Quality Segment

200

assay

≥98% (TLC)

mp

196-198 °C (lit.)

solubility

ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

Cl.CC(C)NC[C@@H](O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m1./s1

InChI key

ZMRUPTIKESYGQW-PFEQFJNWSA-N

Description

General description

With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

Biochem/physiol Actions

Less active enantiomer of propranolol.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	P0884	P8688	40543
Sigma-Aldrich P0689 (R)-(+)-Propranolol hydrochloride	Sigma-Aldrich P0884 (±)-Propranolol hydrochloride	Sigma-Aldrich P8688 (S)-(−)-Propranolol hydrochloride	Supelco 40543 (±)-Propranolol hydrochloride
assay ≥98% (TLC)	assay ≥99% (TLC)	assay ≥98% (TLC)	assay ≥98.5% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility ethanol: 10 mg/mL, H₂O: 50 mg/mL, DMSO: <14.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL	solubility -
originator AstraZeneca	originator AstraZeneca	originator AstraZeneca	originator -
mp 196-198 °C (lit.)	mp -	mp 193-195 °C (lit.)	mp -

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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