N5636

3-Nitropropionic acid

≥97% (HPLC), powder or crystals, mitochondrial complex II inhibitor

• Linear Formula: O₂N(CH₂)₂CO₂H
• CAS Number: 504-88-1
• Molecular Weight: 119.08
• Beilstein: 1759889
• EC Number: 208-003-0
• MDL number: MFCD00007406
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278593
• NACRES: NA.77

Properties

• product name: 3-Nitropropionic acid, ≥97%
• biological source: synthetic
• Assay: ≥97%
• form: powder or crystals
• color: white to light yellow
• mp: 68-70 °C (lit.)
• solubility: alcohol: may be light yellow 100 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(CC[N+]([O-])=O)=O
• InChI: 1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
• InChI key: WBLZUCOIBUDNBV-UHFFFAOYSA-N

Description

Application

3-Nitropropionic acid has been used:

• to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
• to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
• as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

Biochem/physiol Actions

Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves