The unit definition for Nystatin is based on the USP reference standard, and its potency is assessed using the USP Nystatin standard. The initial material, nystatin, possesses a unit activity ranging from 4500 to 5000 units/mg. The preparation in question has an approximate potency of 10,000 units/mL, suggesting that the concentration is likely to be around 2 mg/mL. It should be noted that this is a suspension of nystatin in Dulbecco's Phosphate Buffered Saline (DPBS), not merely in water.
N1638
Nystatin Suspension
suspension, non-animal origin, suitable for cell culture, BioReagent
Synonym(s):
Fungicidin, Mycostatin
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Product Name
Nystatin Suspension, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture
product line
BioReagent
Quality Level
form
suspension
concentration
10,000 unit/mL in DPBS
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
yellow
antibiotic activity spectrum
fungi
yeast
Mode of action
cell membrane | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O
InChI
1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key
VQOXZBDYSJBXMA-QEKUPDCNSA-N
General description
Chemical structure: polyene
Application
Nystatin suspension has been used:
- to inhibit caveolin-mediated endocytosis[1]
- as a component of Eagle′s minimum essential medium (EMEM)[2]
- to enumerate lactic acid bacteria (LAB)[3]
- in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.
Biochem/physiol Actions
Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.[4]
Caution
This product is stable at 37°C for three days.
Preparation Note
It is 0.1μ filtered and cell culture tested.
Other Notes
Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Product N1638 , Nystatin Suspension consists of 10,000 units/mL Nystatin in Dulbecco′s Phosphate Buffered Saline. What does "unit" stand for? If I want 50 mg of this product how much equivalent volume will it be?
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