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D-Lactic Dehydrogenase from Lactobacillus leichmannii

Name: <SC>D</SC>-Lactic Dehydrogenase from Lactobacillus leichmannii
Brand: SIGMA

ammonium sulfate suspension, ≥250 units/mg protein (biuret)

Synonym(s):

Lactate, (R)-Lactate:NAD⁺ oxidoreductase, D−LDH

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About This Item

CAS Number:

9028-36-8

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

1.1.1.28 (BRENDA, IUBMB)

MDL number:

MFCD00130907

Specific activity:

≥250 units/mg protein (biuret)

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Properties

form

ammonium sulfate suspension

Quality Segment

200

specific activity

≥250 units/mg protein (biuret)

foreign activity

Malic dehydrogenase <0.5% of base activity

storage temp.

2-8°C

Description

General description

Research area: Cell Signalling D-lactate dehydrogenase belongs to the D-isomer-specific 2-hydroxyacid dehydrogenase family.[1] Lactate dehydrogenase (LD) is a tetramer consisting of two (H and M) subunits. It has five isozymes (LD1 to LD5) and this composition varies in different tissues. LD1 is abundant in the kidney, heart, and erythrocytes. LD5 is found in the liver and skeletal muscles.[2] LD is a ubiquitous molecule found in plants, yeast, mammals, and microorganisms and is a member of the oxidoreductase family.[3]

Biochem/physiol Actions

Lactic dehydrogenase (LDH)plays an important role in the glycolytic pathway where it converts pyruvate tolactate by using NAD⁺ as a co-factor. It is considered animportant molecule that can be used in cancer therapy as it acts as aglycolytic inhibitor. Inhibition of LDH is associated with blocking of aerobicglycolysis in tumour cells.[2]

Physical form

Suspension in 3.2 M (NH₄)₂SO₄, pH 6.0

Other Notes

One unit will reduce 1.0 μmole of pyruvate to D-lactate per min at pH 7.0 at 25 °C.

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This Item	L3888	L5135	L2625
Sigma-Aldrich L2011 D-Lactic Dehydrogenase from Lactobacillus leichmannii	Sigma-Aldrich L3888 D-Lactic Dehydrogenase from Lactobacillus leichmannii	Sigma-Aldrich L5135 L-Leucine Dehydrogenase from Bacillus cereus	Sigma-Aldrich L2625 L-Lactic Dehydrogenase from bovine heart
specific activity ≥250 units/mg protein (biuret)	specific activity 150-500 units/mg protein	specific activity ≥60 units/mg protein	specific activity ≥500 units/mg protein
form ammonium sulfate suspension	form lyophilized powder	form lyophilized powder	form ammonium sulfate suspension
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
foreign activity Malic dehydrogenase <0.5% of base activity	foreign activity Malic dehydrogenase <0.5% of base activity	foreign activity -	foreign activity pyruvate kinase ≤0.03%

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Global Trade Item Number

SKU	GTIN
L2011-5KU	04061833949719
L2011-2.5KU	04061838173126

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