G5035
Granulocyte-Macrophage Colony-Stimulating Factor human
GM-CSF, recombinant, expressed in E. coli, suitable for cell culture
Synonym(s):
GM-CSF human
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About This Item
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biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤0.1 ng/mL EC50
mol wt
14.6 kDa
packaging
pkg of 4X5 μg
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
solubility
water: soluble 0.010 mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CSF2(1437) , CSF2(1437)
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General description
Package size based on protein content
Biochem/physiol Actions
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity.
Physical form
Lyophilized from a 0.2 μm filtered, 10 mM sodium citrate, pH 3.5 solution.
Analysis Note
The proliferative activity of human GM-CSF is tested in culture using human TF-1 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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