F0301
Monoclonal Anti-CD56-FITC antibody produced in mouse
clone C5.9, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Monoclonal Anti-CD56, Anti-NKH-1
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About This Item
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biological source
mouse
Quality Level
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
C5.9, monoclonal
form
buffered aqueous solution
mol wt
antigen 150 kDa
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG2bκ
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... NCAM1(4684)
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General description
Prepared by conjugation of fluorescein isothiocyanate isomer 1 (FITC). This green dye is efficiently excited at 495 nm and emits at 525 nm.
Immunogen
A cloned human NK cell line termed JT3
Application
Monoclonal Anti-CD56-FITC antibody produced in mouse is suitable for fluorescence microscopy. It was also used for flow cytometric analysis.
Biochem/physiol Actions
Neural Cell Adhesion Molecule (NCAM or the cluster of differentiation CD56) is a homophilic binding glycoprotein. It is expressed on the surface of neurons, glia, skeletal muscle and natural killer cells. CD56 can also be expressed in normal immature granulocytes at different expression levels in regenerative bone marrow. It is associated with cardiac genes induced by metabolic stress and its expression is associated with worsening hemodynamic parameters and major metabolic genes. CD56 is involved in left ventricular remodeling and can be implicated in heart failure. It is is developmentally regulated and may have an important role in cardiac development.
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 0.2% gelatin and 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A A Reyes et al.
Molecular and cellular biology, 11(3), 1654-1661 (1991-03-01)
The major membrane-associated or transmembrane isoforms of the neural cell adhesion molecule (NCAM) are generated by alternative splicing at the 3' end of the mRNA. Further diversity in NCAM structure is observed in the extracellular region of the polypeptide, where
Kazuo Muroi et al.
Journal of clinical and experimental hematopathology : JCEH, 53(3), 247-250 (2013-12-27)
Bone marrow mononuclear cells from 93 patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation (AHSCT) were analyzed using flow cytometry (FCM). The disease was acute myeloblastic leukemia (50 patients), acute lymphoblastic leukemia, and others. Conditioning was myeloablative (80
Takaki Asano et al.
Frontiers in immunology, 9, 568-568 (2018-04-21)
Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. Heterozygous mutations in PIK3CD, PIK3R1, or PTEN, which are related to the hyperactive phosphoinositide 3-kinase (PI3K) signaling, were recently presented to
E Oviedo-Orta et al.
Immunology, 99(4), 578-590 (2000-05-03)
The distribution and function of connexins (integral membrane proteins assembled into gap junction intercellular communication channels) were studied in human lymphocyte subpopulations. The expression of mRNA encoding connexins in peripheral blood and tonsil-derived T, B and natural killer (NK) lymphocytes
Branka Petricevic et al.
Journal of translational medicine, 11, 307-307 (2013-12-18)
Monoclonal antibodies (mAb), such as trastuzumab are a valuable addition to breast cancer therapy. Data obtained from neoadjuvant settings revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is a major mechanism of action for the mAb trastuzumab. Conflicting results still call into
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