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C8874

CGP-37157

≥98% (HPLC), SERCA antagonist , powder

Synonym(s):

7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

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About This Item

Empirical Formula (Hill Notation):
C15H11Cl2NOS
CAS Number:
Molecular Weight:
324.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Product Name

CGP-37157, ≥98% (HPLC), powder

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1

InChI

1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)

InChI key

KQEPIRKXSUIUTH-UHFFFAOYSA-N

General description

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.

Application

CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.

Biochem/physiol Actions

Specific inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.

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This Item
SML2761SML2760C5174
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble

color

white

color

white to beige

color

white to beige

color

-


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Storage Class

11 - Combustible Solids

wgk

WGK 3



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