The product impurities are not identified or quantified. Please see the product specification sheet:
https://www.sigmaaldrich.com/specification-sheets/457/256/A9043-BULK________SIGMA____.pdf.
A9043
S-Acetylthioglycolic acid N-hydroxysuccinimide ester
≥95% (TLC), powder
Synonym(s):
N-Succinimidyl (acetylthio)acetate, N-Succinimidyl S-acetylthioglycolate, S-Acetylthioglycolic acid NHS ester, SATA
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About This Item
Empirical Formula (Hill Notation):
C8H9NO5S
CAS Number:
Molecular Weight:
231.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7815491
Assay:
≥95% (TLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥95% (TLC)
form
powder
solubility
acetonitrile: 50 mg/mL, DMF: soluble
storage temp.
−20°C
SMILES string
CC(=O)SCC(=O)ON1C(=O)CCC1=O
InChI
1S/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3
InChI key
FLCQLSRLQIPNLM-UHFFFAOYSA-N
Application
Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, couples initially to a molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with 0.05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
Other Notes
Note that the ester couples very efficiently to primary amines compared to other thiolating reagents. In addition, this reagent will neutralize original amine positive charge.
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This Item | |||
|---|---|---|---|
| assay ≥95% (TLC) | assay ≥95.0% (coupling assay to aminopropyl silica gel) | assay ≥98% | assay ≥95% (TLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| solubility acetonitrile: 50 mg/mL, DMF: soluble | solubility DMF: soluble, DMSO: soluble | solubility chloroform: 100 mg/mL, DMF: soluble (lit.)(lit.) | solubility DMF: 25 mg/mL |
| form powder | form - | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hello, Could you tell me the percentage of impurities and define specifically which impurities we can find in this reagent ? Thank you,
1 answer-
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