A7236

Anacardic acid

Histone Acetyl transferase (HAT) inhibitor, powder

• Synonym(s): 2-Hydroxy-6-pentadecylbenzoic acid, 22:0-Anacardic acid, 6-Pentadecylsalicylic acid
• Empirical Formula (Hill Notation): C₂₂H₃₆O₃
• CAS Number: 16611-84-0
• Molecular Weight: 348.52
• UNSPSC Code: 12352106
• PubChem Substance ID: 329770923
• NACRES: NA.77
• MDL number: MFCD07368254
• Form: powder
• Storage condition: protect from light

Properties

• Product Name: Anacardic acid,
• form: powder
• Quality Segment: 100
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: ≥20 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
• InChI: 1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25)
• InChI key: ADFWQBGTDJIESE-UHFFFAOYSA-N

Description

Application

Anacardic acid has been used:

• as a histone acetylase (HAT) inhibitor to study its effects on rat cortical neurons[1]
• as a positive control in acetylation assay in vitro[2]
• as an acetylase inhibitor to study its effects on the ribonucleic acid export 1 (Rae-1) protein acetylation that was transfected in human embryonic kidney cells[3]

Biochem/physiol Actions

Anacardic acid is a HAT (Histone Acetyltransferase) inhibitor.

Anacardic acid is a natural bioactive compound derived from the nutshell of Anacardium occidentale. It possesses anti-fungal, anti-bacterial, anti-termite, and molluscicidales activities. Anacardic acid acts as a therapeutic agent against obesity, cancer, inflammatory disorders, and oxidative damage. It functions as an inhibitor of various enzymes such as lipoxygenase (LOX-1), xanthine oxidase, nuclear factor κ B (NFκB) kinase, tyrosinase, and ureases.[4]

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable