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Cyclo(Arg-Gly-Asp-D-Phe-Val)

Name: Cyclo(Arg-Gly-Asp-D-Phe-Val)
Brand: MM

Potent inhibitor of cell adhesion.

Synonym(s):

Cyclo(Arg-Gly-Asp-D-Phe-Val), RGDFV Peptide, Cyclic

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₈N₈O₇

CAS Number:

137813-35-5

Molecular Weight:

574.63

MDL number:

MFCD00008159

NACRES:

NA.77

UNSPSC Code:

12352202

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

1 N acetic acid: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Description

General description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Biochem/physiol Actions

Cell permeable: no

Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates

Product does not compete with ATP.

Reversible: no

Other Notes

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	347436	189485	A8052
Sigma-Aldrich 182015 Cyclo(Arg-Gly-Asp-D-Phe-Val)	Sigma-Aldrich 347436 GGACK	Sigma-Aldrich 189485 Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable	Sigma-Aldrich A8052 Arg-Gly-Asp
description Potent inhibitor of cell adhesion.	description An irreversible inhibitor of urokinase (IC₅₀ 1 µM) and Factor Xa.	description The Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description ≥97% (TLC)
form solid	form solid	form lyophilized solid	form powder
assay ≥95% (HPLC)	assay ≥80% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (TLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility 1 N acetic acid: 5 mg/mL	solubility water: 50 mg/mL	solubility water: 1 mg/mL, 5% acetic acid: 1 mg/mL, DMSO: 5 mg/mL	solubility -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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