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SAB4500814

Sigma-Aldrich

Anti-Estrogen Receptor-β antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ESR2, ESTRB, Estrogen receptor β, NR3A2

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 59 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ESR2(2100)

General description

Estrogen Receptor-β (ERβ) is a member of the nuclear receptor superfamily. It has nine exons and is mapped to human chromosome 14q23.2.

Anti-Estrogen Receptor-β Antibody detects endogenous levels of total Estrogen Receptor-β protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-beta.

Immunogen Range: 71-120

Application

Anti-Estrogen Receptor-βantibody has been used in western blotting .{42,43}

Biochem/physiol Actions

Estrogen Receptor-β (ERβ) is involved in immune and inflammatory response. In females, estrogen receptor β (ESR2) is expected to play an important role in the progress of MDD (major depressive disorder). Aberrations in ESR2 gene result in bone mineral density variation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women
Ichikawa S, et al.
The Journal of Clinical Endocrinology and Metabolism (2005)
Interaction of estrogen receptor ? and negative life events in susceptibility to major depressive disorder in a Chinese Han female population
Zhang J, et al.
Journal of Affective Disorders (2017)
Ratio of Circulating Estrogen Receptors Beta and Alpha (ER?/ER?) Indicates Endoscopic Activity in Patients with Crohn's Disease
Linares PM, et al.
Digestive Diseases and Sciences (2017)
ER?36, a variant of estrogen receptor ?, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells
Yan Y, et al.
PLoS ONE (2017)
Xinyan Wang et al.
Journal of molecular histology, 52(4), 741-749 (2021-05-29)
Accumulating evidence has suggests that women with advanced endometriosis exhibit alterations in the expression of genes in the endometrium compared to healthy controls. Furthermore, replication stress is a characteristic feature of cancer cells, which results from sustained proliferative signaling induced

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