Skip to Content
Merck
All Photos(3)

Documents

SAB3500209

Sigma-Aldrich

Anti-AGTR1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AT1, Anti-AT1R, Anti-Ang II, Anti-Angiotensin II receptor type 1

Sign Into View Organizational & Contract Pricing


About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AGTR1(185)

Related Categories

General description

Angiotensin II receptor, type 1 (AGTR1) is a G-protein coupled receptor possessing seven transmembrane functional domains. AGTR1 gene spanning around 45.1kb, with five exons, is located on human chromosome 3q21−q25. AGTR1 is highly expressed on endothelial cells, monocytes, podocytes, renal vascular smooth muscle cells and renal arteries.
Angiotensin II receptor, type 1 or AT1 receptor (AGRR1, AT1R) is a receptor for the vasoconstriction peptide angiotensin II involved in the regulation of cardiovascular effects such as blood vasoconstriction (blood pressure), aldosterone and vasopressin secretion, cardiac hypertrophy, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.
Rabbit polyclonal anti-AGTR1 reacts with mouse, human, and rat angiotensin II receptor.

Immunogen

AGTR1 antibody was raised against a 16 amino acid peptide from near the center of human AGTR1.

Application

Anti-AGTR1 antibody produced in rabbit has been used in in situ proximity ligation assay (PLA) and immunoblotting.
Rabbit polyclonal anti-AGTR1 is used to tag angiotensin II receptor for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of angiotensin II receptor in the regulation of processes that affect vascular functions such as blood pressure and blood flow.

Biochem/physiol Actions

Angiotensin II receptor, type 1 (AGTR1) has a key function in vascular smooth muscle contraction and maintenance of vasopressor effects by controlling aldosterone secretion. The binding of angiotensin II to AGTR1 contributes to the proliferation of vascular smooth muscle cells by the activation of G protein. The binding also results in the activation of Ca2+ dependent kinases as IP3 (inositol triphosphate) and MAPK (mitogen-activated protein kinases) for the synthesis of proteins and expression of proto-oncogenes, respectively. AGTR1 is associated with high risk of hypertension and cardiovascular diseases.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500209.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

related product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Association of genetic polymorphisms of renin--angiotensin--aldosterone system-related genes with arterio-venous fistula malfunction in hemodialysis patients
Chen YW, et al.
International Journal of Molecular Sciences, 17(6), 833-833 (2016)
Asako Kumagai et al.
Hypertension (Dallas, Tex. : 1979), 78(1), 138-150 (2021-04-13)
[Figure: see text].
Anti-angiotensin II type 1 receptor and anti-endothelial cell antibodies: a cross-sectional analysis of pathological findings in allograft biopsies
Philogene MC, et al.
Transplantation, 101(3), 608-608 (2017)
A Nenicu et al.
Human reproduction (Oxford, England), 29(5), 1011-1024 (2014-03-01)
Is telmisartan effective in the treatment of endometriosis? Combined blockade of angiotensin II type 1 receptor (AT1R) and activation of peroxisome proliferator-activated receptor (PPAR)-γ by telmisartan inhibits vascularization and growth of murine endometriosis-like lesions. AT1R and PPAR-γ are involved in
Hypomethylation of the angiotensin II type I receptor (AGTR1) gene along with environmental factors increases the risk for essential hypertension
Lin J, et al.
Cardiology, 137(2), 126-135 (2017)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service