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M2295

Sigma-Aldrich

Myelin Basic Protein from guinea pig brain

≥80% (SDS-PAGE), lyophilized powder, from guinea pig brain

Synonym(s):

MBP

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

guinea pig brain

Quality Level

Assay

≥80% (SDS-PAGE)

form

lyophilized powder

technique(s)

cell based assay: suitable

UniProt accession no.

application(s)

cell analysis

storage temp.

−20°C

Gene Information

guinea pig ... MBP(100731253)

General description

Myelin Basic Protein (MBP) expressed in guinea pig brain contains 167 amino acids and has a molecular weight of 18,256Da.
Research area: Cell SignallingMyelin basic protein (MBP) is an important constituent of the myelin sheath of CNS (central nervous system). It is an auto-immunogen.

Application

Myelin Basic Protein fromguinea pig brain has been used as a kinase substrate: to analyse in vitrokinase activity, in protein phosphorylation analysis, in ATG1 kinaseassay

Biochem/physiol Actions

Mutation of the myelin basic protein gene induces dysmyelination; used to induce experimental allergic encephalomyelitis.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Quality

May contain traces of urea-glycine buffer salts.

Principle

Used as a kinase substrate.

related product

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sequence of guinea pig myelin basic protein.
Deibler GE
Journal of Neurochemistry, 43(1), 100-105 (1984)
Metallic gold slows disease progression, reduces cell death and induces astrogliosis while simultaneously increasing stem cell responses in an EAE rat model of multiple sclerosis
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J A Last et al.
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