I9404
Interleukin-10/Fc Chimera (non-lytic) human
>98% (SDS-PAGE), recombinant, expressed in NS.1 cells, buffered aqueous solution
Synonym(s):
IL-10:Fc (non-lytic) human
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About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in NS.1 cells
Assay
>98% (SDS-PAGE)
form
buffered aqueous solution
mol wt
98 kDa
packaging
pkg of 10 μg
impurities
endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL10(3586)
General description
The gene IL-10 (interleukin-10) is mapped to human chromosome 1q31-32. It is secreted by monocytes and lymphocytes.
Biochem/physiol Actions
IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.
Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.
Other Notes
Dimeric fusion protein consisting of human IL-10 fused to mutant human IgG1 Fc.
Physical form
Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Maciej Pastuszczak et al.
Human immunology, 76(7), 469-472 (2015-06-24)
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. Increased production of IL-10 has been found in late syphilis, presumably creating favorable conditions for bacteria persistence. Single-nucleotide polymorphisms (SNPs) within the promoter of IL-10 gene have been found to influence IL-10
C Gérard et al.
The Journal of experimental medicine, 177(2), 547-550 (1993-02-01)
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be of particular interest in preventing endotoxin-induced toxicity. We therefore examined the effects of IL-10 administration before lipopolysaccharide (LPS)
Lucia Elena Alvarado-Arnez et al.
PloS one, 10(9), e0136282-e0136282 (2015-09-05)
Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine
Manal Mohamed Makhlouf et al.
Laboratory medicine, 45(3), 211-219 (2014-07-23)
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Interleukin 4 (IL4) and interleukin 10 (IL10) are important immunoregulatory
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