This product is sold as a white, photosensitive solid. The data sheet indicates solubility is 2.5 g/mL in water or 300 mg/mL in ethanol. No information is available regarding solution stability after solubilizing the cocaine. A certified reference standard is available as product C1528, with a concentration of 1 mg/mL in methanol. The recommended storage temperature for this product is 2-8 °C. A random Certificate of Analysis shows the product has a 3-year expiration date from the date of quality release.
C5776
Cocaine hydrochloride
Synonym(s):
Ecgonine methyl ester benzoate hydrochloride
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C17H21NO4 · HCl
CAS Number:
Molecular Weight:
339.81
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
form
powder
Quality Level
drug control
USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
application(s)
forensics and toxicology
SMILES string
Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
InChI
1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
InChI key
PIQVDUKEQYOJNR-VZXSFKIWSA-N
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Application
Cocaine hydrochloride has been used:
- in saline control to study the effects of cocaine self-administration in mouse brain[1]
- as adopamine (DA), noradrenaline (NA), and serotonin (5-HT) reuptake inhibitor to evoke neurotransmitter release in artificial fish cerebrospinal fluid (aCSF)[2]
- to examine conditioning to intravenous cocaine hydrochloride[3]
Biochem/physiol Actions
Inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.
Inhibits the dopamine, norepinephrine, and serotonin transporters.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
Target Organs
Central nervous system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Maria E Burkovetskaya et al.
ACS chemical neuroscience, 11(15), 2231-2242 (2020-07-02)
Cocaine addiction remains a major public concern throughout the world especially in developed countries. In the last three decades, significant achievements have led to a greater understanding of the signaling pathways involved in the development of cocaine addiction; however, there
Benoît Forget et al.
Progress in neurobiology, 197, 101898-101898 (2020-08-26)
Cocaine addiction is a chronic and relapsing disorder with an important genetic component. Human candidate gene association studies showed that the single nucleotide polymorphism (SNP) rs16969968 in the α5 subunit (α5SNP) of nicotinic acetylcholine receptors (nAChRs), previously associated with increased
Michel Engeln et al.
Biological psychiatry, 87(11), 992-1000 (2019-12-21)
We previously showed that the transcription factor Egr3 (early growth response 3) is oppositely regulated in nucleus accumbens (NAc) cell subtypes 24 hours following cocaine exposure and bidirectionally mediates cocaine-related behaviors in male rodents. Overexpressing Egr3 in D2 receptor-containing medium
Ernest T Chivero et al.
Frontiers in cell and developmental biology, 8, 573-573 (2020-08-28)
MicroRNA-124 (miR-124), a brain-enriched microRNA, is known to regulate microglial quiescence. Psychostimulants such as cocaine have been shown to activate microglia by downregulating miR-124, leading, in turn, to neuroinflammation. We thus rationalized that restoring the levels of miR-124 could function
Maria E Burkovetskaya et al.
Neuroscience letters, 728, 134951-134951 (2020-04-13)
The evidence showing the involvement of microglial activation in the development of drug addiction remain scarce as microglia have not been systematically investigated in self-administered mice, a gold standard rodent model for drug addiction. Here we established the stable cocaine
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I wonder that if I dissolve the cocaine in saline, is it stable for long term? Should I storage it in -20 or 4? For how long?
1 answer-
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