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04473

2,4-Pyridinedicarboxylic acid

Name: 2,4-Pyridinedicarboxylic acid
Brand: SIGMA

≥98.0%

Synonym(s):

Lutidinic acid

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About This Item

Empirical Formula (Hill Notation):

C₇H₅NO₄

CAS Number:

499-80-9

Molecular Weight:

167.12

NACRES:

NA.25

PubChem Substance ID:

329747930

UNSPSC Code:

12352106

EC Number:

207-892-2

MDL number:

MFCD00006296

Beilstein/REAXYS Number:

131631

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Properties

Quality Level

100

assay

≥98.0%, 98.0-102.0% (T)

InChI

1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChI key

MJIVRKPEXXHNJT-UHFFFAOYSA-N

Description

Application

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. . 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.

Line H Kristensen et al.

The FEBS journal, 279(11), 1905-1914 (2012-03-17)

Dynamic methylations and demethylations of histone lysine residues are important for gene regulation and are facilitated by histone methyltransferases and histone demethylases (HDMs). KDM5B/Jarid1B/PLU1 is an H3K4me3/me2-specific lysine demethylase belonging to the JmjC domain-containing family of histone demethylases (JHDMs). Several

Competitive inhibition of glutamate dehydrogenase reaction.

Rajarshi Choudhury et al.

FEBS letters, 581(14), 2733-2736 (2007-05-29)

Irrespective of their pyridine nucleotide specificity, all glutamate dehydrogenases share a common chemical mechanism that involves an enzyme bound 'iminoglutarate' intermediate. Three compounds, structurally related to this intermediate, were tested for the inhibition of purified NADP-glutamate dehydrogenases from two Aspergilli

Enabling lead discovery for histone lysine demethylases by high-throughput RapidFire mass spectrometry.

Sue E Hutchinson et al.

Journal of biomolecular screening, 17(1), 39-48 (2011-08-24)

A high-throughput RapidFire mass spectrometry assay is described for the JMJD2 family of Fe(2+), O(2), and α-ketoglutarate-dependent histone lysine demethylases. The assay employs a short amino acid peptide substrate, corresponding to the first 15 amino acid residues of histone H3

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Global Trade Item Number

SKU	GTIN
143618-100G	04061838734921
143618-500G	04061832278599
04473-5G	04061838630681