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Supelco

Carazolol

analytical standard

Synonym(s):

1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol, 4-(2-Hydroxy-3-isopropylamino-propoxy)carbazole

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About This Item

Empirical Formula (Hill Notation):
C18H22N2O2
CAS Number:
57775-29-8
Molecular Weight:
298.38
Beilstein:
3620576
EC Number:
260-945-1
MDL number:
MFCD00864588
UNSPSC Code:
41116107
PubChem Substance ID:
329757996
NACRES:
NA.24

grade

analytical standard

Quality Level

200

Assay

≥98.5% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

mp

133-137 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12

InChI

1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3

InChI key

BQXQGZPYHWWCEB-UHFFFAOYSA-N

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General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706030, T706025

Application

Carazolol may be used as a reference standard for the determination of the analyte:
  • In swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
  • In animal tissues by high-performance liquid chromatography with electrochemical detection.

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF3309V
WXBF1115V
WXBF1414V
0000280507
WXBF1644V

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Stefano Costanzi
Journal of medicinal chemistry, 51(10), 2907-2914 (2008-04-30)
The publication of the crystal structure of the beta2-adrenergic receptor (beta2-AR) proved that G protein-coupled receptors (GPCRs) share a structurally conserved rhodopsin-like 7TM core. Here, to probe to which extent realistic GPCR structures can be recreated through modeling, carazolol was
Determination of residues of carazolol and a number of tranquilizers in swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
Keukens HJ and Aerts MML
Journal of Chromatography A, 464, 149- 161 (1991)
Sid Topiol et al.
Biochemical pharmacology, 78(1), 11-20 (2009-05-19)
G-protein-coupled receptor (GPCR) proteins [Lundstrom KH, Chiu ML, editors. G protein-coupled receptors in drug discovery. CRC Press; 2006] are the single largest drug target, representing 25-50% of marketed drugs [Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are
Xi Zhang et al.
Analytical chemistry, 82(3), 1100-1108 (2010-01-12)
To examine the molecular details of ligand activation of G-protein coupled receptors (GPCRs), emphasis has been placed on structure determination of these receptors with stabilizing ligands. Here we present the methodology for receptor dynamics characterization of the GPCR human beta(2)
Chris de Graaf et al.
Journal of medicinal chemistry, 51(16), 4978-4985 (2008-08-06)
The recently solved high-resolution X-ray structure of the beta2 adrenergic receptor has been challenged for its ability to discriminate inverse agonists/antagonists from partial/full agonists. Whereas the X-ray structure of the ground state receptor was unsuitable to distinguish true ligands with
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