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Key Documents

513030

Sigma-Aldrich

PD 169316

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Synonym(s):

PD 169316, 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

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About This Item

Empirical Formula (Hill Notation):
C20H13FN4O2
CAS Number:
Molecular Weight:
360.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange-yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)

InChI key

BGIYKDUASORTBB-UHFFFAOYSA-N

General description

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC50= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
p38 MAP kinase
Product competes with ATP.
Reversible: yes
Target IC50: 89 nM against p38 MAP kinase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Nath, R., et al. 2001. Cell Mol. Biol. Lett.6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbonesCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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