1463326

Nicotine Related Compound A

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Anatabine, (RS)-Anatabine, (±)-Anatabine, 1,2,3,6-Tetrahydro-2,3′-bipyridine, 1,2,3,6-Tetrahydro-2,3′-dipyridine
• Empirical Formula (Hill Notation): C₁₀H₁₂N₂
• CAS Number: 2743-90-0
• Molecular Weight: 160.22
• MDL number: MFCD00078278
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• agency: USP
• API family: nicotine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: N1C(CC=CC1)c2cnccc2
• InChI: 1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h1-4,6,8,10,12H,5,7H2
• InChI key: SOPPBXUYQGUQHE-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nicotine Related Compound A USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as:

• Nicotine
• Nicotine Polacrilex

Biochem/physiol Actions

Anatabine is a blood-brain barrier penetrant minor alkaloid, a cholinergic agonist, isolated from Solanaceae plant family that exhibits anti-inflammatory properties.

Anatabine is a blood-brain barrier penetrant minor alkaloid, a cholinergic agonist, isolated from Solanaceae plant family that exhibits anti-inflammatory properties. Apparently, anti-inflammatory properties of anatabine are partially mediated by inhibition of STAT3 and p65 NFkB phosphorylation. Anatabine decreases the transcription and protein synthesis of β-secretase (BACE-1), and appears to ameliorate experimental autoimmune thyroiditis and encephalomyelitis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H319
• pcodes: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable