1173042

Desloratadine

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex^®, NSC 675447
• Empirical Formula (Hill Notation): C₁₉H₁₉ClN₂
• CAS Number: 100643-71-8
• Molecular Weight: 310.82
• MDL number: MFCD00871949
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749543
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: desloratadine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
• InChI: 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChI key: JAUOIFJMECXRGI-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desloratadine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Desloratadine Orally Disintegrating Tablets
• Desloratadine Tablets

Biochem/physiol Actions

Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Legal Information

Clarinex is a registered trademark of Schering Corp.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable