Skip to Content
MilliporeSigma

Key Documents

Skip To

T7665

Tyrphostin 51

≥98%

Synonym(s):

2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C13H8N4O3
CAS Number:
Molecular Weight:
268.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98%
Form:
powder
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


biological source

synthetic (organic)

Quality Segment

assay

≥98%

form

powder

potency

0.8 μM IC50

solubility

DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red

storage temp.

2-8°C

SMILES string

NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N

InChI

1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+

InChI key

JKNOYWVMHPMBEL-UNXLUWIOSA-N

Gene Information

Application

Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.

Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.
Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
T7040T7165T4182
description

≥98%

description

≥98%

description

≥98%

description

≥98%

assay

≥98%

assay

≥98%

assay

≥98%

assay

≥98%

form

powder

form

solid

form

powder

form

solid

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red

solubility

chloroform: soluble 50 mg/mL, clear, light yellow, DMSO: soluble

solubility

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

solubility

H2O: insoluble, methylene chloride: soluble 10 mg/mL, 0.1 M HCl: soluble <0.4 mg/mL, DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless, 2-hydroxypropyl-β-cyclodextrin: insoluble, ethanol: soluble 10 mg/mL, 0.1 M NaOH: insoluble

Gene Information

human ... CDK2(1017), EGFR(1956)

Gene Information

human ... EGFR(1956)

Gene Information

human ... CDK2(1017)

Gene Information

human ... EGFR(1956)
mouse ... Egfr(13649)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters