SRP4633
VEGF-C human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
VEGFC, Vascular Endothelial Growth Factor-C
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About This Item
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biological source
human
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
lyophilized
mol wt
15-16 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VEGFC(7424)
General description
The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3.
Application
VEGF-C human has been used to determine cell proliferation and survival.
Biochem/physiol Actions
VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.
Physical form
Lyophilized without additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis
Kinashi H, et al.
Kidney International, 92(4), 850-863 (2017)
Angiogenesis: From Basic Science to Clinical Applications, 58-58 (2006)
The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy
Aldebasi YH, et al.
International Journal of Clinical and Experimental Medicine, 6(4), 239-239 (2013)
Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor-C in a mouse model of lung cancer
Qin T, et al.
Cancer Science, 109(8), 2469-2469 (2018)
Takeshi Hisamatsu et al.
Clinical & experimental metastasis, 32(8), 789-798 (2015-10-08)
The aim of this study is to investigate the significance of lymphatic space invasion (LSI) and tumor VEGF-C expression in the lymphatic spread of ovarian cancer. By performing immunostaining using human ovarian cancer specimens, we first investigated the association between
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