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SRE0003

Sigma-Aldrich

Thrombin from bovine plasma

Suitable for manufacturing of diagnostic kits and reagents

Synonym(s):

Factor IIa

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About This Item

CAS Number:
9002-04-4
Enzyme Commission number:
3.4.21.5 (BRENDA, IUBMB)
EC Number:
232-648-7
MDL number:
MFCD00166053
UNSPSC Code:
12352204
NACRES:
NA.54
Pricing and availability is not currently available.

biological source

bovine plasma

Quality Level

400

form

powder

specific activity

80-500 NIH units/mg protein

application(s)

diagnostic assay manufacturing

shipped in

wet ice

storage temp.

−20°C

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1 of 4

This Item
T1063T4648T6884
Thrombin from bovine plasma Suitable for manufacturing of diagnostic kits and reagents

SRE0003

Thrombin from bovine plasma

Thrombin from human plasma lyophilized powder, ≥2800 NIH units/mg protein (E1%/280, 18.3)

T1063

Thrombin from human plasma

Thrombin from bovine plasma lyophilized powder, 40-500 NIH units/mg protein (biuret)

T4648

Thrombin from bovine plasma

Thrombin from human plasma lyophilized powder, ≥2,000 NIH units/mg protein (E1%/280, 18.3)

T6884

Thrombin from human plasma

biological source

bovine plasma

biological source

-

biological source

bovine plasma

biological source

human plasma

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

application(s)

diagnostic assay manufacturing

application(s)

diagnostic assay manufacturing

application(s)

-

application(s)

-

shipped in

wet ice

shipped in

-

shipped in

wet ice

shipped in

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.

Unit Definition

Activity is expressed in NIH units obtained by direct comparison to a NIH thrombin reference standard.

Analysis Note

Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard, Lot K.
The NIH assay procedure uses 0.2 mL of diluted plasma (1:1 with saline) as a substrate and 0.1 mL of thrombin sample (stabilized in a 1% buffered albumin solution) based on a modification of the method of Biggs. Only clotting times in the range of 15-25 seconds are used for determining thrombin concentrations.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000420731
0000420728
0000399470
0000399470
0000420728

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