SML3663

CAY10499

≥98% (HPLC)

• Synonym(s): Benzyl 4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenylcarbamate, CAY 10499, CAY-10499, LEI 103, LEI-103, LEI103, Phenylmethyl N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate, [4-(5-Methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-carbamic acid phenylmethyl ester
• Empirical Formula (Hill Notation): C₁₈H₁₇N₃O₅
• CAS Number: 359714-55-9
• Molecular Weight: 355.34
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD12912259
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

CAY10499 is a potent inhibitor against fatty acid amide hydrolase, hormone-sensitive lipase, and monoglyceride lipase (FAAH/HSL/MGL(MAGL) IC50 = 86/90/92 nM). Note: CAY10499 is reported to be irreversible by Muccioli et al. (PMID 18855964) and reversible by Minkkila et al. (PMID 19472270). Reported IC50 values vary depending greatly on pre-incubation time, substrates, enzyme source, as well as other experimental parameters employed.

Potent inhibitor against fatty acid amide hydrolase (FAAH), hormone-sensitive lipase (HSL), and monoglyceride lipase (MAGL, MGL).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable