SML3357

Rasarfin

≥98% (HPLC)

• Synonym(s): N-(3-Chloro-4-(4-isobutyrylpiperazin-1-yl)phenyl)benzofuran-2-carboxamide, N-[3-Chloro-4-[4-(2-methyl-1-oxopropyl)-1-piperazinyl]phenyl]-2-benzofurancarboxamide
• Empirical Formula (Hill Notation): C₂₃H₂₄ClN₃O₃
• CAS Number: 674359-73-0
• Molecular Weight: 425.91
• UNSPSC Code: 12352200
• NACRES: NA.32
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC2=C(C=CC=C2)O1)NC3=CC=C(N4CCN(CC4)C(C(C)C)=O)C(Cl)=C3
• InChI key: SRZCCUYFJZQLGE-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Dual Ras and ARF6 inhibitor that inhibits both receptor internalization and signaling

Rasarfin is a dual Ras and ARF6 inhibitor that inhibits both receptor internalization and signaling. It blocks agonist-mediated internalization of AT1R and other GPCRs. Rasarfin potently inhibits agonist induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR. It prevents cancer cell proliferation.

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable