SML3324

UNC6852

≥98% (HPLC)

• Synonym(s): (2S,4R)-1-((S)-2-(4-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• Empirical Formula (Hill Notation): C₄₃H₄₈N₁₀O₆S
• CAS Number: 2688842-08-0
• Molecular Weight: 832.97
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: O=C([C@H](C(C)(C)C)NC(CCCNC(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)=O)=O)N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5
• InChI key: PPNNFXIBKLCMTI-WXEAQWFJSA-N

Description

Biochem/physiol Actions

UNC6852 is a potent degrader of polycomb repressive complex 2 (PRC2) that targets EED. UNC6852 selectively degrades PRC2 components EED (embryonic ectoderm development), EZH2 (enhancer of zeste homolog 2), and SUZ12 (suppressor of zeste homolog 12) via recruitment of VHL. UNC6852 exhibit anticancer activities in model systems.

potent degrader of polycomb repressive complex 2 (PRC2) that targets EED

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable