SML1180

WWL229

≥98% (HPLC)

• Synonym(s): 2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
• Empirical Formula (Hill Notation): C₁₆H₂₂N₂O₅
• CAS Number: 1338575-28-2
• Molecular Weight: 322.36
• UNSPSC Code: 12161501
• PubChem Substance ID: 329825704
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: oil
• color: colorless to light yellow
• storage temp.: 2-8°C
• SMILES string: O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
• InChI: 1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
• InChI key: XVBRVSAGMWRVCK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC₅₀ of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable