SML0828

FPH2

≥98% (HPLC)

• Synonym(s): 4-(3-(5-Chloro-2-methoxyphenyl)thioxureido)-1-ethyl-1H-pyrazole-3-carboxamide, 4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide, BRD-9424
• Empirical Formula (Hill Notation): C₁₄H₁₆ClN₅O₂S
• CAS Number: 957485-64-2
• Molecular Weight: 353.83
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• InChI: 1S/C14H16ClN5O2S/c1-3-20-7-10(12(19-20)13(16)21)18-14(23)17-9-6-8(15)4-5-11(9)22-2/h4-7H,3H2,1-2H3,(H2,16,21)(H2,17,18,23)
• InChI key: PCHRYHSDDPPZBV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

FPH2 (BRD-9424) induced functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH2 induced hepatocyte doublings at a rate consistent with reported liver regeneration kinetics. FPH2 can be used in conjunction with FH1 (BRD-K4477), which induces a more mature phenotype.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable