SML0475

CGP36742

≥97% (NMR)

• Synonym(s): P-(3-Aminopropyl)-P-butyl-phosphinic acid, SGS 742
• Empirical Formula (Hill Notation): C₇H₁₈NO₂P
• CAS Number: 123690-78-8
• Molecular Weight: 179.20
• MDL number: MFCD00882735
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825430
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (NMR)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 10 mg/mL (clear solution, warmed)
• storage temp.: room temp
• SMILES string: CCCCP(O)(=O)CCCN
• InChI: 1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
• InChI key: ONNMDRQRSGKZCN-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CGP36742 was the first orally active GABAB-selective antagonist. The IC₅₀ for blocking GABAergic transmission is 36 μM. Oral administration of CGP36742 in rats blocks baclofen-induced neuronal depression, and reduces learning deficit and passive avoidance in an olfactory bulbectomy depression model.

Features and Benefits

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Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H319
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable