Anti-Cyclin A Antibody detects endogenous levels of total Cyclin A protein.
CCNA1 (cyclin A1) is a member of the highly conserved cyclin family. There are two A-type cyclins, namely cyclin A1 and cyclin A2. Cyclin A1 is expressed at high levels in testis and expressed at low levels in most other tissues. This gene is mapped to human chromosome 13q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Cyclin A.
Immunogen Range: 221-270
Application
Anti-Cyclin A antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper)
Biochem/physiol Actions
CCNA1 (cyclin A1) controls cell apoptosis. Cyclin A2 is required for DNA replication and proliferation in somatic cells. CCNA1 plays an important role in head and neck carcinoma and cervical and nasopharyngeal cancers.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16.
Weiss D, et al.
BMC Cancer, 12(1), 259-259 (2012)
Correlation of CCNA1 promoter methylation with malignant tumors: a meta-analysis introduction.
Yang B, et al.
BioMed Research International, 2015, 134027-134027 (2015)
Depletion of HOXA5 inhibits the osteogenic differentiation and proliferation potential of stem cells from the apical papilla.
Li W, et al.
Cell Biology International, 42(1), 45-52 (2018)
PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression
Qu X, et al.
Journal of Translational Medicine, 13(1), 301-301 (2015)
Mesenchymal stem cells (MSCs) are a prospective cell source for tissue regeneration due to their self-renewal abilities and potential to differentiate into different cell lineages, but the molecular mechanisms of the directed differentiation and proliferation are still unknown. Recently, multiple
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