SAB4503272

Anti-CASP-1 (Cleaved-Asp²¹⁰) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): ICE, IL-1 β, IL-1 β converting enzyme, IL-1BC, caspase-1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 25 kDa; antigen 45 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P29466
• UniProt accession no.: P29466
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: proteolytically cleaved (Asp210)
• Gene Information: human ... CASP1(834)

Description

General description

Anti-CASP-1 (Cleaved-Asp²¹⁰) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp²¹⁰) protein.

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human IL-1 beta.

Immunogen Range: 161-210

Biochem/physiol Actions

Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable