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Key Documents

SAB4502922

Sigma-Aldrich

Anti-TAK1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

M3K7, MAP3K7, Mitogen-activated protein kinase kinase kinase 7, TGF-β- activated kinase 1, Transforming growth factor-β-activated kinase 1

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About This Item

MDL number:
MFCD02097469
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 67 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

O43318

UniProt accession no.

O43318

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAP3K7(6885)

General description

Anti-TAK1 antibody detects endogenous levels of total TAK1 protein.
The TAK1 (Transforming growth factor β activated kinase 1) gene is mapped to human chromosome 6q15. It encodes for a mitogen-activated protein kinase 7 containing serine-threonine/tyrosine-protein kinase catalytic domain and a coiled-coil domain at the C-terminal.

Immunogen

The antiserum was produced against synthesized peptide derived from human TAK1.

Immunogen Range: 161-210

Biochem/physiol Actions

TAK1 (Transforming growth factor β (TGF-β) activated kinase 1) is activated by TGF-β and other inflammatory stimuli such as chemical and physical agents causing stress, cytokines, and microorganism moieties. TAK1 participates in mitogen-activated protein kinase (MAPK)-p38 signaling pathway. TAK1 is involved in the regulation of osteogenesis. TAK1 is important for productive autophagy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1.
Hashimoto K
Antioxidants & Redox Signaling, 25(17), 953-964 (2016)
TAK1 is involved in the autophagy process in retinal pigment epithelial cells.
Green YA
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 94(2), 188-196 (2016)
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Wade EM
American Journal of Human Genetics, 99(2), 392-406 (2016)
Martina Kluth et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(7), 975-983 (2013-02-02)
6q12-22 is the second most commonly deleted genomic region in prostate cancer. Mapping studies have described a minimally deleted area at 6q15, containing MAP3K7/TAK1, which was recently shown to have tumor suppressive properties. To determine prevalence and clinical significance of
Heterozygous Mutations in MAP3K7, Encoding TGF-?-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.
Le Goff C
American Journal of Human Genetics, 99(2), 407-413 (2016)

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