S8197

SMER28

>99% (HPLC), solid

• Synonym(s): 6-Bromo-N-2-propenyl-4-quinazolinamine
• Empirical Formula (Hill Notation): C₁₁H₁₀BrN₃
• CAS Number: 307538-42-7
• Molecular Weight: 264.12
• NACRES: NA.77
• PubChem Substance ID: 329824598
• UNSPSC Code: 12352200
• MDL number: MFCD02166825
• Assay: >99% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: >99% (HPLC)
• form: solid
• solubility: DMSO: >20 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: Brc1ccc2ncnc(NCC=C)c2c1
• InChI: 1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
• InChI key: BCPOLXUSCUFDGE-UHFFFAOYSA-N

Description

Application

SMER28 may be used in mTOR-mediated signaling studies.

Biochem/physiol Actions

SMER28 is a small molecule modulator of mammalian autophagy.

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves